Motivation: This course addresses the growing need within modern engineering to integrate biotechnological knowledge with engineering approaches in order to develop advanced solutions in genetic engineering, regenerative medicine, and emerging therapeutic technologies. For PhD students in engineering, understanding the biological mechanisms underlying genome editing, tissue aging, and mechanobiology is essential to contribute effectively and interdisciplinarily to cutting-edge research and innovation.Objectives: The course aims to provide doctoral students with the scientific foundations of genetic engineering, tissue engineering, and robotic applications in oncology and regenerative medicine, while also addressing the ethical and technical challenges of these emerging technologies. By the end of the course, students will be able to understand, evaluate, and integrate complex biological concepts into advanced engineering frameworks, supporting their engagement in multidisciplinary research projects.